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Similar PEM-like symptoms, including exertional exhaustion and post-exertion symptom exacerbation, are also reported in GWS patients (Baraniuk, 2022) and FM (McManimen and Jason, 2017), with co-morbid FM and ME/CFS resulting in increased illness severity and greater symptoms burden (McManimen and Jason, 2017)

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Its ability to cross the blood-brain barrier makes SFN particularly relevant for protection against neurodegenerative disorders, as shown in various mouse models